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Quantitative Trait Locus (QTL) Analysis 1

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This is the first of a two-part series that describes the methods and uses of QTL analysis.

QTL Analysis 1 - Objectives and Overview

Patrick Byrne
Department of Soil and Crop Sciences at Colorado State University, USA
Welcome to the QTL Analysis 1 on-line lesson! Use the arrow buttons at the bottom of the page to move through the lesson materials. Before starting the lesson, please note these helpful navigation tips.

Lesson Navigation Tips:

  • Click on ’Animations’ button found to the left in order to view the animation which supplements this lesson. You can also click on the animation icon within the text.
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Understanding the genetic control of quantitative traits helps plant breeders improve crop yield, disease resistance, end-use quality, and other important characteristics. Quantitative trait locus (QTL) analysis is a methodology that combines DNA marker and phenotypic trait data to locate and characterize genes that influence quantitative traits. In this pair of lessons (QTL Analysis 1 and 2) we will provide an overview of the methods and uses of QTL analysis, rather than detailed explanations of this complex statistical methodology. Upon completing this lesson (QTL Analysis 1) you should be able to:

  • Explain the basic concepts of QTL analysis.
  • List the main components of a QTL study.
  • Name three types of population used in QTL analysis and describe how they are developed.
  • Describe the steps in phenotypic evaluation in a QTL study.
  • Explain the process and outputs of marker evaluation in a QTL study.

Development of this lesson was supported in part by USDA Initiative for Future Agriculture and Food Systems (IFAFS)
and the Cooperative State Research, Education, & Extension Service,
U.S. Dept of Agriculture under Agreement Number 00-52100-9710.
Any opinions, findings, conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture.


Posted: 2012-03-12 12:57:24 by Patcharee Konghirun
I just work with QTL of NCLB and found 8 QTLs for resistance. From this QTL and marker we thought that we can convert any line for NCLB resistance but it's not true because when we would like to start new line which susceptible to NCLB, the question from GPL, 'Did the new line relate to the original line of QTL mapping' So it's mean that still some limitation to use MAS and we would like to know 'What else are the limitation of MAS and can we break that blockers?

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